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Antipsychotic Drug Controls "Breakthrough" Nausea and Vomiting after Chemotherapy

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Caring About Cancer Patients

Chemotherapy

Many Women whose Tumors Disappear after Chemotherapy Have Mastectomies

NCI: Posted on Thursday, October 11, 2012 12:22 PM
Many women with breast cancer whose tumors disappear after presurgical chemotherapy have amastectomy instead of breast-conserving surgery, according to a re-analysis of data from theNeoALTTO trial. The results were presented September 30 at the 2012 European Society for Medical Oncology Congress  (ESMO).

In the phase III trial, investigators randomly assigned women with HER2-positive breast cancer to receive trastuzumab, lapatinib, or both drugs for a total of 18 weeks prior to surgery.
Categories: Cancer Information/Updates, Breast Cancer, Chemotherapy
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Experimental Drug Based on Plant Toxin Targets and Kills Tumor Cells

NCI: Posted on Thursday, July 12, 2012 11:58 PM
 
Researchers have engineered a drug that can deliver a potent cell-killing toxin to tumors while largely sparing normal tissues. The drug, known asG202, shrankxenografttumors of several human cancers in mice, includingprostate,breast,kidney, andbladdercancer, and had relatively few toxic effects. On the basis of thesefindings, reported June 27 inScience TranslationalMedicine, researchers have initiated an early-phaseclinical trialof G202 in patients with advanced cancer.
G202 delivers its toxic payload—a potent
Categories: Cancer Facts/Statistics, Cancer Information/Updates, Chemotherapy
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Some Children with Hodgkin Lymphoma May Not Need Radiation Therapy

Posted on Thursday, July 12, 2012 11:25 PM
Children with Hodgkin lymphoma who have favorable clinical features and who respond early to chemotherapy may not need treatment with radiation. The finding, reported in the June 27JAMA, is from a clinical trial of 88 patients with low-risk disease.

Patients who had an early complete response to the chemotherapy regimen used in the trial and were not treated with radiation therapy (as stipulated in the study protocol) had 5-year survival rates similar to those of children who did not have the same response to chemotherapy and therefore required radiation.
Categories: Cancer Information/Updates, Children and cancer, Chemotherapy
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Antipsychotic Drug Controls "Breakthrough" Nausea and Vomiting after Chemotherapy

NCI: Posted on Thursday, May 31, 2012 4:32 PM
In a phase III clinical trial, the antipsychotic drug olanzapine (Zyprexa) was significantly more effective than metoclopramide (Reglan) in controlling chemotherapy-induced nausea and vomiting (CINV) that occurs in some patients despite preventive treatment for these side effects. (Olanzapine is approved by the Food and Drug Administration to treat schizophrenia and bipolar disorder.) Dr. Rudolph Navari of Indiana University School of Medicine-South Bend presented the results at a May 16 press briefing held in advance of the American Society of Clinical Oncology (ASCO) annual meeting .
Categories: New Cancer Info., Clinical Trials for Cancer, Chemotherapy
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